Background/Objectives: Caffeine is widely recognized as an ergogenic aid, yet evidence regarding its acute effects on repeated sprint ability (RSA) remains inconsistent. This systematic review and meta-analysis aimed to evaluate the effects of acute caffeine ingestion on RSA across different populations, exercise modalities, and dosage levels. Methods: A comprehensive literature search was conducted in the PubMed, EBSCO, Cochrane Library, Web of science, and Scopus databases. Data were pooled using the weighted mean difference (WMD) with 95% confidence interval (CI). Results: Thirteen studies met the inclusion criteria. Acute caffeine ingestion significantly enhanced RSA peak power output (PPO) compared with placebo (WMD, 5.28; 95% CI, 2.49 to 8.07; p = 0.0002). Subgroup analyses revealed significant improvements in both males (WMD, 13.11; 95% CI, 5.63 to 20.59; p = 0.0006) and females (WMD, 4.03; 95% CI, 1.10 to 6.97; p = 0.007). A caffeine dose of =6 mg/kg body weight (BW) produced greater ergogenic benefits (WMD, 6.67; 95% CI, 3.32 to 10.02; p < 0.0001) than lower doses (WMD, 2.16; 95% CI, -2.87 to 7.19; p = 0.40). Moreover, a more pronounced enhancement was observed in cycling-based RSA (WMD, 8.77; 95% CI, 1.98 to 15.56; p = 0.01) compared with running-based protocols (WMD, 4.56; 95% CI, 1.58 to 7.55; p = 0.003). Conclusions: Acute caffeine ingestion significantly enhances RSA, particularly at doses =6 mg/kg BW. This effect is consistent across both male and female participants, with no statistically significant sex difference observed in the pooled analysis. These findings reinforce caffeine`s role as an effective ergogenic aid for optimizing high-intensity intermittent performance, with the strongest benefits evident in cycling exercise.
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