Objective of the study was to analyze the etiological factors of influence on a sport-specific endotoxin aggression. Methods and structure of the study. We tested endotoxin of gram-negative intestinal bacteria in the blood plasma, plus antibacterial humoral immunity in the 18-20 year-old athletes (n=79) versus the Reference Group of virtually healthy 20-40 year-olds (RG, n=30). We used the systemic endotoxinemia and antiendotoxin immunity test method developed by the Institute of General and Clinical Pathology (RF Patents No. 2011993, 2088936, 2093825); and rated the antibacterial humoral immunity by an enzyme immunoassay to find contents of the antibacterial antibodies to the following antigens of opportunistic bacteria: Pseudomonas aeruginosa, Escherichia coli, Proteus, bacteroids, Klebsiella, bifidumbacteria and Candida antigens. The test data were processed by the MS Excel 5.0 statistical toolkit, with the data array differences rated significant at p<0.05. Results and conclusions. The study found a direct correlation between the blood plasma endotoxin and antibodies to bifidobacteria indicative of a high permeability of the intestinal barrier. The group with high antibodies to bifidobacteria was diagnosed with endotoxin aggression of different sport-specific etiologies that exposes the group to a high risk of an adaptation failure (de-adaptation).
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