Sudden death in an athlete is a tragic event. There is a strong social imperative to implement effective means of predicting and preventing sudden death in athletes. However, the design and implementation of a solution seems unobtainable [2]. Part Two discusses how novel attributes of systems biology and digital technology are capable of delivering high quality, low cost athletic screening. The merit of a transformative idea does not necessarily predict its adoption. The greatest barrier to change lies in the acquiescence to familiar practices even in light of new ideas and technology. The current thought in athletic screening is more centered on specific disease associations (rule-in principle), [3-5] and much less about the sensitivity of pathophysiologic causality (ruleout principle) [5-8]. A solution will languish until the expert community takes direct action to embrace 21st century systems based medicine, causality, and digital technology [7,9,10]. The first step is to break the code of silence by open public discourse (publish and speak about the transformative attributes of systems based medicine).The second step is to make everyone accountable (causal prediction and prevention must be 100%). The third and final step is to focus on how to define the components of systems based medicine, determine how these components interact with one another, and delineate the dynamics of these components in determining pre-emergent disease states [10].
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