There is a paucity of well-controlled anti-doping interventions. We developed and evaluated the efficacy of a doping prevention program for adolescents - the Hercules program. The program is different from most anti-doping interventions in the combination of theoretical lessons with practical strength training and inclusion of three groups of participants. A total of 202 high school students (females = 98) aged 15-21 years (mean = 16.9) were randomised to the three groups: control (n = 50), theory only (n = 88), and theory with workout (n = 64). Participants completed baseline and posttest questionnaires including demographic, doping use, and psychophysical items/measures. Data were analysed using chi-square tests and mixed between-within analysis of variance. From baseline to posttest, the theory with workout group gained a higher knowledge of anabolic-androgenic steroids (AAS) and their harmful effects as well as a higher increase in strength training self-efficacy. The Hercules program seems valuable in providing adolescents knowledge on AAS and their harmful effects as well as positive strength training skills. The program elucidates the benefits of combining anti-doping education with practical strength training in doping prevention
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