In a recent report, Schulte et al. (2012) have measured elevated serum levels of S100B protein in athletes in the absence of traumatic brain injury (TBI) of which high serum S100B is one accepted biomarker. The authors have hypothesized that such an increase may be consequent to tissue hypoperfusion reflected by blood lactate concentrations and/or increased serotonin activity reflected by prolactin levels. However, sodium lactate infusion into human subjects resulted in no changes in serum S100B, and enhanced prolactin levels were also excluded as a cause of increased serum S100B after physical activity (Schulte et al. 2012). Thus, the authors concluded that neither increased blood lactate nor serum prolactin plays an exclusive role in the regulation of S100B. Also, the cause of elevated serum S100B in athletes has remained unidentified.
© Copyright 2013 European Journal of Applied Physiology. Springer. Alle Rechte vorbehalten.