Key Points Performing unilateral resistance training can increase muscle strength not only in the trained limb but also in the contralateral untrained limb, which is known as the cross-education of strength. However, less attention has been paid to the question of whether performing unilateral resistance training can increase muscular endurance in the contralateral untrained limb (i.e., cross-education of muscular endurance). The current body of the literature does not provide sufficient evidence to draw clear conclusions whether a cross-education of muscular endurance is present. Therefore, further research with a nonexercise control group (i.e., randomized controlled trials) is necessary to draw strong conclusions. The cross-education of muscular endurance (if it exists) may be potentially driven by neural adaptations (via bilateral access and/or cross-activation models that lead to cross-education of strength) and increased tolerance to exercise-induced discomfort.
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