Context: Pseudoephedrine (PSE) is an over-the-counter decongestant that might have ergogenic effects. The World Anti-Doping Agency has prohibited large doses (>150 µg/mL) of PSE, while the National College Athletic Association (NCAA) does not include it on their banned-substance list. Purpose: This study examined the effect of body-weight dosing of PSE on 800-m-run times of NCAA female runners. Methods: Fifteen NCAA female track athletes volunteered to participate in the randomized, double-blind, crossover design. Participants were given 2.5 mg/kg PSE or placebo in trials separated by a week. Ninety minutes postingestion, participants completed an 800-m individual time trial on an indoor track. Finishing time was recorded with an automated video timing device. Heart rate and anxiety state scores were recorded immediately after each trial. Results: Fourteen runners completed both trials, and 1 was an outlier: N = 13. Despite the dose being well above normal therapeutic levels (144 ± 17 mg), there was no significant difference (P = .92) in 800-m times between PSE (2:39.447 ± 9.584) and placebo (2:39.372 ± 9.636) trials, in postexercise heart rate (P = .635; PSE = 177.9 ± 14.5 beats/min, placebo = 178.4 ± 18.5 beats/min), or in anxiety-state levels (P = .650; PSE = 38.4 ± 11.6, placebo = 38.1 ± 8.8). Conclusion: A 2.5-mg/kg dose of PSE had no effect on 800-m performance for female NCAA runners. More research is needed to determine if PSE should be a specified banned substance.
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