Purpose This study aimed to investigate whether a genetic-based algorithm derived from ACE (rs1799752) and ACTN3 (rs1815739) polymorphisms could be utilized to predict the magnitude of improvements in vertical jump performance following high-intensity resistance training. Methods Twenty male professional footballers (age 18.7 ± 0.6 year; height 169.8 ± 2.7 cm, body mass 62.3 ± 6.0 kg) were recruited and allocated into "low" and "high" weighted total genotype score (TGS) groups based on the number of power/strength-associated ACE and ACTN3 polymorphisms. Explosive power of the lower limb was assessed by vertical jump test before and after an eight-week high-intensity resistance training. Results The magnitude of improvement was found to be significantly different between the high and low TGS groups (p = 0.042; d = 0.98) with greater improvement being observed in the high TGS group (15.4%) as compared to the low TGS group (2.8%) following the resistance training intervention. Further stratification of the players into tertiles based on the percentage change score in vertical jump showed that a large proportion of footballers among the high responders belonged to the high TGS group (83.3%). Conclusions In conclusion, this study showed the combined influence of ACE and ACTN3 polymorphisms on the magnitude of improvements in vertical jump performance following high-intensity resistance training. This finding may contribute towards the development of a more personalised resistance training regime that targets explosive power adaptations.
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