L-carnitine is a derivative of two essential amino acids synthesized in the liver and kidneys that our body needs for energy. In the bioenergetics of skeletal muscle, carnitine plays crucial roles. A severe reduction in muscular activity is associated with skeletal muscle carnitine insufficiency. Since L-carnitine supplement is known as a fat burner, its use among athletes has become more common in recent years. This review's objective is to assess the potential mechanistic effects of L-carnitine supplementation on athletic performance. In this context, the literature in the SportDiscus, EMBASE, PubMed and Google Scholar databases was scanned during a 15-year period to gather the data from the publications screened within the scope of SCI, SCI-Expanded, and ESCI. Consequently, it may be argued that taking carnitine supplementation improves athletic performance through a number of processes; including the maintenance of glycogen.
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