Maximizing muscle hypertrophy is a primary goal for bodybuilders and resistance-trained individuals, driving the exploration of advanced resistance training strategies that extend beyond traditional programming. This review comprehensively examines the theories, mechanisms, and practical applications of various advanced training techniques, including supersets, drop sets, lengthened partials, pre-exhaustion training, rest-pause training, forced repetitions, pyramidal training, interset stretching, and blood flow restriction. These methods aim to enhance mechanical tension, metabolic stress, and muscle activation in effort to promote muscle growth. Although many of these strategies offer time-efficient alternatives to conventional training, current evidence suggests that they do not consistently surpass traditional resistance training in muscle growth when volume is equated. Despite their widespread use in bodybuilding, research is often limited by short study durations, small sample sizes, and a lack of studies involving competitive bodybuilders. This review highlights key findings from existing literature, identifies gaps requiring further investigation, and provides practical recommendations for integrating advanced training strategies into evidence-based hypertrophy programs.
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