Taken together, in our opinion the large number of possibly interacting genes and non-genetic factors is only one reason why it is so difficult to determine the ontogenetic bases of handedness and other forms of hemispheric asymmetries. Another reason is that we simply do not know enough about what exactly constitutes a handedness phenotype, and how many there are. For the time being, we would like to suggest that future studies on the genetics of hemispheric asymmetries should include both a preference measure (e.g., EHI) and a performance measure (e.g., the peg board task), and that both direction and strength should be reported for those two measures in addition to a composite score such as a laterality quotient. Furthermore, research on the genetics of handedness may benefit from a stronger integration of brain activation measures, e.g., motor cortex activation differences between left- and right-handers during finger tapping or similar tasks.
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