The purpose of this investigation was to elucidate the changes in cf-DNA as it relates to fluctuations in resistance training workloads and intensities. The relationship between cell free DNA (cf-DNA), C-reactive protein (CRP), creatine kinase (CK), testosterone (T), cortisol (C), testosterone-cortisol ratio (T:C), body mass and body composition were also examined. Eight weightlifters (5 males and 3 females, age = 25 ± 3.5 yr, body mass = 88.3 ± 22.7 kg, height = 173.8 ±8.4 cm) volunteered to participate in this study. Venous blood samples, body mass and body composition were taken six times, each corresponding to the end of a training phase. CK (p = 0.018, ?² = 0.409) and CK %? (p < 0.001, ?² = 0.594) were the only biochemical variables to reach statistical significance at any point. A number of statistically significant correlations were found among variables. VLD4wk was related to CK % (r = 0.86), VLD4wk %? was related CK %? (r = 0.86) and TID1wk was related to CRP (r = 0.83). cf-DNA %? was correlated with CRP and CRP %? (r = 0.83 and 0.86, respectively). CRP and CRP %? were correlated with BF % (r = 0.94 and 0.92, respectively). CK and CK %? were both related to T:C (r = 0.94 and 0.89, respectively) and T:C %? (r = 0.87 and 0.86, respectively). The correlation between cf-DNA and CRP suggests that cf-DNA may be a valuable indicator of inflammation in weightlifters.
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